Tuesday 25 September 2012

Check to your hands for signs that you could be genetically predisposed to gluten intollerance



Are you gluten intolerant?

What is gluten intolerance; tests and treatment, Braly’s sign


Gluten intolerance is caused by genetic predisposition combined with gluten consumption and triggering factors like stressful events.  People with Braly’s sign, where the little finger is much shorter than the last joint of the ring finger, are much more likely to be gluten intolerant than the general population.


Figure 1 Positive Braly's sign
 


Gluten is a protein compound found in some grains (highest in Wheat).  Gluten is what makes dough “sticky” and pliable, giving bread its chewy consistency.  Extra gluten is often added to shop bought wheat breads to make them even softer and chewier than if only plain wheat flour is used.  Although wheat contains the highest concentration of gluten of all the grains, it is also present in Barley, Rye, Oats and Spelt.  

The mucous membrane lining of the intestines become inflamed in people that are gluten intolerant when gluten is consumed.  This constant inflammation may eventually damage the intestinal lining to a point that absorption of nutrients is negatively affected.

Celiac disease is diagnosed if gluten intolerance is bad enough to cause atrophy (thinning) of the intestinal lining with severe nutrient depletion.

The most commonly experienced symptoms of gluten intolerance are abdominal bloating and cramps, flatulence,  diarrhoea and/ or constipation, with a whole range of less common symptoms e.g.  eczema, sinusitis, weight gain, swelling, fatigue and low iron levels.


Testing for gluten intolerance by blood tests will only be positive if there is severe digestive inflammation and gluten is still consumed (blood anti-transaminase, anti-myelysin and anti-gliadin).  Genetic tests can also highlight a tendency to gluten intolerance (the markers of HLA-DQ2 or HLA-DQ8 haplotype) but are extremely expensive and only shows a predisposition to gluten intolerance and not that the disease is present.  An anti-gliadin stool test can be performed if the patient is currently eating gluten , and bioresonance tests e.g. BIORES or BEST tests can be preformed (which are cost effective).  

Treatment of gluten intolerance is complete or partial avoidance of gluten, depending on the severity of the symptoms.  In people that are highly gluten intolerant as little as a knifepoint (1g) of gluten can cause intestinal damage.  L-glutamine (an amino acid that is only related to gluten by name) is highly effective in repairing intestinal lining damage.

References:
Braly, J and Hoggan, R; Dangerous grains 2009
http://en.wikipedia.org/wiki/Gluten

Monday 10 September 2012

Is stress making you sick?


Is stress making you sick?
Add up your stress values to check your risk
I am often asked whether stress can make you sick.
 The answer is yes, definitely and there are lots of studies proving this link going back many decades.
(check table below )
Holmes and Rahe did a study in 1967 where they looked for indications whether stress causes illness in 5000 medical case files.  They found a clear correlation and they compiled the Holmes and Rahe Stress Scale which gives numerical values according to the likelihood of different stresses causing illness. 
They found that positive experiences can often have similar chances of causing illness as a negative experience.  Buying a house seems to be almost as bad as losing a house!

To measure stress add up the values for your stressful events for the past year
Score of 300+: At risk of illness.
Score of 150-299+: Risk of illness is moderate (reduced by 30% from the above risk).
Score 150-: Only have a slight risk of illness
.
Holmes and Rahe Stress Scale
Life event
Life change units
Death of a spouse
100
Divorce
73
Marital separation
65
Imprisonment
63
Death of a close family member
63
Personal injury or illness
53
Marriage
50
Dismissal from work
47
Marital reconciliation
45
Retirement
45
Change in health of family member
44
Pregnancy
40
Sexual difficulties
39
Gain a new family member
39
Business readjustment
39
Change in financial state
38
Death of a close friend
37
Change to different line of work
36
Change in frequency of arguments
35
Major mortgage
32
Foreclosure of mortgage or loan
30
Change in responsibilities at work
29
Child leaving home
29
Trouble with in-laws
29
Outstanding personal achievement
28
Spouse starts or stops work
26
Begin or end school
26
Change in living conditions
25
Revision of personal habits
24
Trouble with boss
23
Change in working hours or conditions
20
Change in residence
20
Change in schools
20
Change in recreation
19
Change in church activities
19
Change in social activities
18
Minor mortgage or loan
17
Change in sleeping habits
16
Change in number of family reunions
15
Change in eating habits
15
Vacation
13
Christmas
12
Minor violation of law
11
This table is taken from "The Social Readjustment Rating Scale", Thomas H. Holmes and Richard H. Rahe, Journal of Psychosomatic Research, Volume 11, Issue 2, August 1967, Pages 213-218, Copyright © 1967 Published by Elsevier Science Inc. All rights reserved.